Characterizing In Vivo Pharmacodynamics of Carbapenems against Acinetobacter baumannii in a Murine Thigh Infection Model To Support Breakpoint Determinations | Zendy

Shawn H. MacVane | Zendy; Jared L. Crandon | Zendy; David P. Nicolau | Zendy

Open Access

Characterizing In Vivo Pharmacodynamics of Carbapenems against Acinetobacter baumannii in a Murine Thigh Infection Model To Support Breakpoint Determinations

Author(s) -

Shawn H. MacVane,

Jared L. Crandon,

David P. Nicolau

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02029-13

Subject(s) - acinetobacter baumannii , breakpoint , in vivo , pharmacodynamics , biology , microbiology and biotechnology , pseudomonas aeruginosa , acinetobacter , antibiotics , medicine , pharmacology , genetics , pharmacokinetics , gene , bacteria , chromosomal translocation

Pharmacodynamic profiling data of carbapenems for Acinetobacter spp. are sparse. This study aimed to determine the pharmacodynamic targets of carbapenems for Acinetobacter baumannii based on a range of percentages of the dosing interval in which free drug concentrations remained above the MIC (fT>MIC) in the neutropenic murine thigh infection model. fT>MIC values of 23.7%, 32.8%, and 47.5% resulted in stasis, 1-log reductions, and 2-log reductions in bacterial density after 24 h, respectively. The pharmacodynamic targets of carbapenems for A. baumannii demonstrated in vivo are similar to those of other Gram-negative bacteria.

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