Evaluating 5-Nitrothiazoles as Trypanocidal Agents | Zendy

Ivan P. O’Shea | Zendy; Mohammed Shahed | Zendy; Benjamín AguileraVenegas | Zendy; Shane R. Wilkinson | Zendy

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Evaluating 5-Nitrothiazoles as Trypanocidal Agents

Author(s) -

Ivan P. O’Shea,

Mohammed Shahed,

Benjamín AguileraVenegas,

Shane R. Wilkinson

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02006-15

Subject(s) - trypanocidal agent , pharmacology , anti infective agents , medicine , virology , biology , trypanosoma brucei , microbiology and biotechnology , antimicrobial , biochemistry , gene

The growth-inhibitory properties of a 5-nitrothiazole series were evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency toward the parasite while exhibiting little cytotoxic effect on mammalian cells, with this antiparasitic activity dependent on expression of a type I nitroreductase by the trypanosome. We conclude that the 5-nitrothiazole class of nitroheterocyclic drugs may represent a new lead in the treatment of human African trypanosomiasis.

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