Detection of Echinocandin-Resistant Candida glabrata in Blood Cultures Spiked with Different Percentages of FKS2 Mutants | Zendy

María Ángeles Bordallo-Cardona | Zendy; Carlos SánchezCarrillo | Zendy; Emilio Bouza | Zendy; Patricia Muñóz | Zendy; Pilar Escribano | Zendy; Jesús Guinea | Zendy

Open Access

Detection of Echinocandin-Resistant Candida glabrata in Blood Cultures Spiked with Different Percentages of FKS2 Mutants

Author(s) -

María Ángeles Bordallo-Cardona,

Carlos SánchezCarrillo,

Emilio Bouza,

Patricia Muñóz,

Pilar Escribano,

Jesús Guinea

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.02004-18

Subject(s) - echinocandin , candida glabrata , microbiology and biotechnology , biology , mutant , echinocandins , fungemia , candida albicans , fluconazole , antifungal , genetics , gene , caspofungin

Infections caused by the coexistence ofCandida glabrata echinocandin-resistant and echinocandin-susceptible cells may be possible, and the detection ofFKS mutants when the proportions ofFKS mutants are underrepresented poses a problem. We assessed the role of EUCAST and methods directly performed on positive blood cultures—Etest (ETDIR ) and anidulafungin-containing agar plate assays—for detecting resistance inC. glabrata isolates containing different amounts of echinocandin-susceptible and -resistantCandida glabrata isolates.

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