Monitoring the Efficacy of Chloroquine-Primaquine Therapy for Uncomplicated Plasmodium vivax Malaria in the Main Transmission Hot Spot of Brazil | Zendy

Simone Ladeia-Andrade | Zendy; Maria José Menezes | Zendy; Taís Nóbrega de Sousa | Zendy; Ana Carolina Rios Silvino | Zendy; Jaques F. de Carvalho | Zendy; Laís Camoese Salla | Zendy; Odailton Amaral Nery | Zendy; Gladson Naber P. de Melo | Zendy; Rodrigo M. Corder | Zendy; Priscila T. Rodrigues | Zendy; Marcelo U. Ferreira | Zendy

Open Access

Monitoring the Efficacy of Chloroquine-Primaquine Therapy for Uncomplicated Plasmodium vivax Malaria in the Main Transmission Hot Spot of Brazil

Author(s) -

Simone Ladeia-Andrade,

Maria José Menezes,

Taís Nóbrega de Sousa,

Ana Carolina Rios Silvino,

Jaques F. de Carvalho,

Laís Camoese Salla,

Odailton Amaral Nery,

Gladson Naber P. de Melo,

Rodrigo M. Corder,

Priscila T. Rodrigues,

Marcelo U. Ferreira

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01965-18

Subject(s) - primaquine , chloroquine , malaria , plasmodium vivax , vivax malaria , plasmodium falciparum , piperaquine , drug resistance , medicine , virology , artemisinin , biology , pharmacology , immunology , microbiology and biotechnology

EmergingPlasmodium vivax resistance to chloroquine (CQ) may undermine malaria elimination efforts in South America. CQ-resistantP. vivax has been found in the major port city of Manaus but not in the main malaria hot spots across the Amazon Basin of Brazil, where CQ is routinely coadministered with primaquine (PQ) for radical cure of vivax malaria.

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