Population Pharmacokinetic Study of Prophylactic Fluconazole in Preterm Infants for Prevention of Invasive Candidiasis | Zendy

Yu Kyong Kim | Zendy; Ju Young Lee | Zendy; Jaeseong Oh | Zendy; Sujin Rhee | Zendy; Seung Han Shin | Zendy; Seo Hyun Yoon | Zendy; SeungHwan Lee | Zendy; HanSuk Kim | Zendy; KyungSang Yu | Zendy

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Population Pharmacokinetic Study of Prophylactic Fluconazole in Preterm Infants for Prevention of Invasive Candidiasis

Author(s) -

Yu Kyong Kim,

Ju Young Lee,

Jaeseong Oh,

Sujin Rhee,

Seung Han Shin,

Seo Hyun Yoon,

SeungHwan Lee,

HanSuk Kim,

KyungSang Yu

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01960-18

Subject(s) - fluconazole , pharmacokinetics , medicine , volume of distribution , population , dosing , regimen , nonmem , pharmacology , antifungal , environmental health , dermatology

Fluconazole is an antifungal agent with reported evidence for its prophylactic effect against systemic fungal infection in preterm infants. The aim of this study was to build a population pharmacokinetic model to evaluate the pharmacokinetic characteristics of intravenous and oral fluconazole in preterm infants with the current prophylactic fluconazole dosing regimen.

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