Prevention of Biofilm Colonization by Gram-Negative Bacteria on Minocycline-Rifampin-Impregnated Catheters Sequentially Coated with Chlorhexidine | Zendy

Mohamed A. Jamal | Zendy; Joel Rosenblatt | Zendy; Ray Hachem | Zendy; Ying Jiang | Zendy; Egbert Pravinkumar | Zendy; Joseph L. Nates | Zendy; Anne-Marie P. Chaftari | Zendy; Issam Raad | Zendy

Open Access

Prevention of Biofilm Colonization by Gram-Negative Bacteria on Minocycline-Rifampin-Impregnated Catheters Sequentially Coated with Chlorhexidine

Author(s) -

Mohamed A. Jamal,

Joel Rosenblatt,

Ray Hachem,

Ying Jiang,

Egbert Pravinkumar,

Joseph L. Nates,

Anne-Marie P. Chaftari,

Issam Raad

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01959-13

Subject(s) - microbiology and biotechnology , stenotrophomonas maltophilia , acinetobacter baumannii , pseudomonas aeruginosa , enterobacter cloacae , antimicrobial , chlorhexidine , silver sulfadiazine , klebsiella pneumoniae , gram negative bacteria , minocycline , acinetobacter , sulfadiazine , colistin , antibiotics , biology , bacteria , medicine , escherichia coli , wound healing , surgery , biochemistry , genetics , dentistry , gene

Resistant Gram-negative bacteria are increasing central-line-associated bloodstream infection threats. To better combat this, chlorhexidine (CHX) was added to minocycline-rifampin (M/R) catheters. Thein vitro antimicrobial activity of CHX-M/R catheters against multidrug resistant, Gram-negativeAcinetobacter baumannii ,Enterobacter cloacae ,Escherichia coli ,Klebsiella pneumoniae ,Pseudomonas aeruginosa , andStenotrophomonas maltophilia was tested. M/R and CHX-silver sulfadiazine (CHX/SS) catheters were used as comparators. The novel CHX-M/R catheters were significantly more effective (P < 0.0001) than CHX/SS or M/R catheters in preventing biofilm colonization and showed better antimicrobial durability.

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