Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1 | Zendy

Ebere Sonoiki | Zendy; Christian Nsanzabana | Zendy; Jennifer Legac | Zendy; Kirthana M. V. Sindhe | Zendy; Joseph L. DeRisi | Zendy; Philip J. Rosenthal | Zendy

Open Access

Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1

Author(s) -

Ebere Sonoiki,

Christian Nsanzabana,

Jennifer Legac,

Kirthana M. V. Sindhe,

Joseph L. DeRisi,

Philip J. Rosenthal

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01949-16

Subject(s) - lopinavir , plasmodium falciparum , virology , protease inhibitor (pharmacology) , biology , malaria , medicine , human immunodeficiency virus (hiv) , antiretroviral therapy , immunology , viral load

The HIV protease inhibitor lopinavir inhibitsPlasmodium falciparum aspartic proteases (plasmepsins) and parasite development, and children receiving lopinavir-ritonavir experienced fewer episodes of malaria than those receiving other antiretroviral regimens. Resistance to lopinavir was selectedin vitro over ∼9 months, with ∼4-fold decreased sensitivity. Whole-genome sequencing of resistant parasites showed a mutation and increased copy number inpfmdr1 and a mutation in a protein of unknown function, but no polymorphisms in plasmepsin genes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research