Pharmacokinetics of Dapivirine Transfer into Blood Plasma, Breast Milk, and Cervicovaginal Fluid of Lactating Women Using the Dapivirine Vaginal Ring | Zendy

Lisa Noguchi | Zendy; Craig Hoesley | Zendy; Cliff Kelly | Zendy; Rachel Scheckter | Zendy; Katherine Bunge | Zendy; Annaléne Nel | Zendy; Mark A. Marzinke | Zendy; Craig W. Hendrix | Zendy; Charlene S. Dezzutti | Zendy; Sharon L. Hillier | Zendy; Debra L. Bogen | Zendy; Jeanna Piper | Zendy; Richard H. Beigi | Zendy

Open Access

Pharmacokinetics of Dapivirine Transfer into Blood Plasma, Breast Milk, and Cervicovaginal Fluid of Lactating Women Using the Dapivirine Vaginal Ring

Author(s) -

Lisa Noguchi,

Craig Hoesley,

Cliff Kelly,

Rachel Scheckter,

Katherine Bunge,

Annaléne Nel,

Mark A. Marzinke,

Craig W. Hendrix,

Charlene S. Dezzutti,

Sharon L. Hillier,

Debra L. Bogen,

Jeanna Piper,

Richard H. Beigi

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01930-18

Subject(s) - vaginal ring , breast milk , medicine , pharmacokinetics , population , breastfeeding , gynecology , human immunodeficiency virus (hiv) , obstetrics , family planning , chemistry , research methodology , virology , biochemistry , environmental health , pathology

Breastfeeding (BF) women are an important population for biomedical HIV prevention strategies, but they are rarely included in trials. The 25-mg dapivirine vaginal ring (VR) reduced women’s risk of sexually transmitted HIV infection in two phase 3 trials conducted in Africa.

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