Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase via both Nonobligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus | Zendy

Jeffrey M. Chamberlain | Zendy; Katherine Sortino | Zendy; Phiroze Sethna | Zendy; Andrew Bae | Zendy; Randall Lanier | Zendy; Robert A. Bambara | Zendy; Stephen Dewhurst | Zendy

Open Access

Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase via both Nonobligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus

Author(s) -

Jeffrey M. Chamberlain,

Katherine Sortino,

Phiroze Sethna,

Andrew Bae,

Randall Lanier,

Robert A. Bambara,

Stephen Dewhurst

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01925-18

Subject(s) - cidofovir , virology , polymerase , dna polymerase , polymerase chain reaction , virus , biology , dna , microbiology and biotechnology , gene , genetics

Human adenovirus (AdV) can cause fatal disease in immune-suppressed individuals, but treatment options are limited, in part because the antiviral cytidine analog cidofovir (CDV) is nephrotoxic. The investigational agent brincidofovir (BCV) is orally bioavailable, nonnephrotoxic, and generates the same active metabolite, cidofovir diphosphate (CDVpp).

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