Is One Sample Enough? β-Lactam Target Attainment and Penetration into Epithelial Lining Fluid Based on Multiple Bronchoalveolar Lavage Sampling Time Points in a Swine Pneumonia Model | Zendy

Ana Motos | Zendy; Joseph L. Kuti | Zendy; Gianluigi Li Bassi | Zendy; Antoní Torres | Zendy; David P. Nicolau | Zendy

Open Access

Is One Sample Enough? β-Lactam Target Attainment and Penetration into Epithelial Lining Fluid Based on Multiple Bronchoalveolar Lavage Sampling Time Points in a Swine Pneumonia Model

Author(s) -

Ana Motos,

Joseph L. Kuti,

Gianluigi Li Bassi,

Antoní Torres,

David P. Nicolau

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01922-18

Subject(s) - bronchoalveolar lavage , pneumonia , penetration (warfare) , lactam , beta lactam , microbiology and biotechnology , medicine , immunology , antibiotics , chemistry , biology , lung , mathematics , operations research , stereochemistry

Describing the disposition of antimicrobial agents at the site of infection is crucial to guide optimal dosing for investigational agents. For antibiotics in development for the treatment of nosocomial pneumonia, concentrations in the epithelial lining fluid (ELF) of the lung are frequently determined from a bronchoscopy at a single time point.

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