Preexposure to Isavuconazole Increases the Virulence of Mucorales but Not Aspergillus fumigatus in a Drosophila melanogaster Infection Model | Zendy

Sebastian Wurster | Zendy; Russell E. Lewis | Zendy; Nathaniel D. Albert | Zendy; Dimitrios P. Kontoyiannis | Zendy

Open Access

Preexposure to Isavuconazole Increases the Virulence of Mucorales but Not Aspergillus fumigatus in a Drosophila melanogaster Infection Model

Author(s) -

Sebastian Wurster,

Russell E. Lewis,

Nathaniel D. Albert,

Dimitrios P. Kontoyiannis

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01896-18

Subject(s) - mucorales , aspergillus fumigatus , voriconazole , virulence , biology , mucormycosis , aspergillus , microbiology and biotechnology , aspergillosis , drosophila melanogaster , virology , medicine , immunology , antifungal , genetics , pathology , gene

Breakthrough mucormycosis in patients receiving isavuconazole prophylaxis or therapy has been reported. We compared the impact of isavuconazole and voriconazole exposure on the virulence of clinical isolates ofAspergillus fumigatus and differentMucorales species in aDrosophila melanogaster infection model.

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