vanO , a New Glycopeptide Resistance Operon in Environmental Rhodococcus equi Isolates | Zendy

Dereje Dadi Gudeta | Zendy; Arshnee Moodley | Zendy; Valeria Bortolaia | Zendy; Luca Guardabassi | Zendy

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vanO , a New Glycopeptide Resistance Operon in Environmental Rhodococcus equi Isolates

Author(s) -

Dereje Dadi Gudeta,

Arshnee Moodley,

Valeria Bortolaia,

Luca Guardabassi

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01880-13

Subject(s) - operon , rhodococcus equi , glycopeptide , biology , genetics , microbiology and biotechnology , homology (biology) , open reading frame , gene , peptide sequence , antibiotics , virulence , escherichia coli

We describe here the sequence and gene organization of a new glycopeptide resistance operon (vanO) in Rhodococcus equi from soil. The vanO operon has low homology to enterococcal van operons and harbors a vanHOX cluster transcribed in the direction opposite that of the vanS-vanR regulatory system and composed of three open reading frames with unknown function. This finding has clinical interest, since glycopeptides are used to treat R. equi infections and resistance has been reported in clinical isolates.

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