MSH2 Gene Point Mutations Are Not Antifungal Resistance Markers in Candida glabrata | Zendy

María Ángeles Bordallo-Cardona | Zendy; Caroline Agnelli | Zendy; Ana Gómez-Núñez | Zendy; Carlos SánchezCarrillo | Zendy; Emilio Bouza | Zendy; Patricia Muñóz | Zendy; Pilar Escribano | Zendy; Jesús Guinea | Zendy

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MSH2 Gene Point Mutations Are Not Antifungal Resistance Markers in Candida glabrata

Author(s) -

María Ángeles Bordallo-Cardona,

Caroline Agnelli,

Ana Gómez-Núñez,

Carlos SánchezCarrillo,

Emilio Bouza,

Patricia Muñóz,

Pilar Escribano,

Jesús Guinea

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01876-18

Subject(s) - candida glabrata , msh2 , point mutation , biology , genetics , gene , antifungal , microbiology and biotechnology , drug resistance , mutation , dna mismatch repair , dna repair

The high rates of antifungal resistance inCandida glabrata may be facilitated by the presence of alterations in theMSH2 gene. We aimed to study the sequence of theMSH2 gene in 124 invasiveC. glabrata isolates causing incident episodes of candidemia (n = 81), subsequent candidemia episodes (n = 9), endocarditis (n = 2), andin vitro -generated echinocandin-resistant isolates (n = 32) and assessed its relationship with genotypes, acquisition of antifungal resistancein vivo andin vitro , and patient prognosis.

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