Mutations at the Ribosomal S10 Gene in Clinical Strains of Staphylococcus aureus with Reduced Susceptibility to Tigecycline | Zendy

M. Ángeles Argudín | Zendy; Sandrine Roisin | Zendy; Magali Dodémont | Zendy; C. hoff | Zendy; A. Deplano | Zendy; Olivier Denis | Zendy

Open Access

Mutations at the Ribosomal S10 Gene in Clinical Strains of Staphylococcus aureus with Reduced Susceptibility to Tigecycline

Author(s) -

M. Ángeles Argudín,

Sandrine Roisin,

Magali Dodémont,

C. hoff,

A. Deplano,

Olivier Denis

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01852-17

Subject(s) - staphylococcus aureus , tigecycline , mutant , microbiology and biotechnology , ribosomal protein , gene , strain (injury) , ribosomal rna , biology , bacteria , 23s ribosomal rna , antibiotics , genetics , rna , ribosome , anatomy

Mutations on the tip of the extended loop of the ribosomal S10 protein have been associated to tigecycline (TGC) resistance in passaged mutants of different bacteria species. This study described the first two clinical TGC-resistantStaphylococcus aureus isolates with these mutations. One strain (TGC MIC = 2 mg/liter) had a 12-nucleotide deletion affecting residues 56 to 59 (HKYK) of the S10 protein. The second strain (TGC MIC = 1 mg/liter) had amino acid substitutions (K57M and Y58F) previously described inS. aureus passaged mutants.

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