Impact of Vancomycin MIC on Treatment Outcomes in Invasive Staphylococcus aureus Infections | Zendy

KyoungHo Song | Zendy; Moonsuk Kim | Zendy; Chung-Jong Kim | Zendy; Jeong Eun Cho | Zendy; Yun Jung Choi | Zendy; Jeong Su Park | Zendy; Soyeon Ahn | Zendy; HeeChang Jang | Zendy; KyungHwa Park | Zendy; SookIn Jung | Zendy; Na-Ra Yoon | Zendy; DongMin Kim | Zendy; JeongHwan Hwang | Zendy; Chang Seop Lee | Zendy; Jae Hoon Lee | Zendy; Yee Gyung Kwak | Zendy; Eu Suk Kim | Zendy; Seong Yeon Park | Zendy; Yoonseon Park | Zendy; Kkot Sil Lee | Zendy; Yeong-Seon Lee | Zendy; Hong Bin Kim | Zendy

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Impact of Vancomycin MIC on Treatment Outcomes in Invasive Staphylococcus aureus Infections

Author(s) -

KyoungHo Song,

Moonsuk Kim,

Chung-Jong Kim,

Jeong Eun Cho,

Yun Jung Choi,

Jeong Su Park,

Soyeon Ahn,

HeeChang Jang,

KyungHwa Park,

SookIn Jung,

Na-Ra Yoon,

DongMin Kim,

JeongHwan Hwang,

Chang Seop Lee,

Jae Hoon Lee,

Yee Gyung Kwak,

Eu Suk Kim,

Seong Yeon Park,

Yoonseon Park,

Kkot Sil Lee,

Yeong-Seon Lee,

Hong Bin Kim

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01845-16

Subject(s) - etest , broth microdilution , staphylococcus aureus , vancomycin , medicine , methicillin resistant staphylococcus aureus , minimum inhibitory concentration , staphylococcal infections , mortality rate , microbiology and biotechnology , antibiotics , biology , bacteria , genetics

There are conflicting data on the association of vancomycin MIC (VAN-MIC) with treatment outcomes inStaphylococcus aureus infections. We investigated the relationship between high VAN-MIC and 30-day mortality and identified the risk factors for mortality in a large cohort of patients with invasiveS. aureus (ISA) infections, defined as the isolation ofS. aureus from a normally sterile site. Over a 2-year period, 1,027 adult patients with ISA infections were enrolled in 10 hospitals, including 673 (66%) patients with methicillin-resistantS. aureus (MRSA) infections. There were 200 (19.5%) isolates with high VAN-MIC (≥1.5 mg/liter) by Etest and 87 (8.5%) by broth microdilution (BMD). The all-cause 30-day mortality rate was 27.4%. High VAN-MIC by either method was not associated with all-cause 30-day mortality, and this finding was consistent across MIC methodologies and methicillin susceptibilities. We conclude that high VAN-MIC is not associated with increased risk of all-cause 30-day mortality in ISA infections. Our data support the view that VAN-MIC alone is not sufficient evidence to change current clinical practice.

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