In Vitro Activity of Sulopenem, an Oral Penem, against Urinary Isolates of Escherichia coli | Zendy

James A. Karlowsky | Zendy; Heather J. Adam | Zendy; Melanie Baxter | Zendy; Andrew Denisuik | Zendy; Philippe LagacéWiens | Zendy; Andrew Walkty | Zendy; Sailaja Puttagunta | Zendy; Michael W. Dunne | Zendy; George G. Zhanel | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

In Vitro Activity of Sulopenem, an Oral Penem, against Urinary Isolates of Escherichia coli

Author(s) -

James A. Karlowsky,

Heather J. Adam,

Melanie Baxter,

Andrew Denisuik,

Philippe LagacéWiens,

Andrew Walkty,

Sailaja Puttagunta,

Michael W. Dunne,

George G. Zhanel

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01832-18

Subject(s) - escherichia coli , microbiology and biotechnology , in vitro , urinary system , enterobacteriaceae , chemistry , biology , biochemistry , gene , endocrinology

Thein vitro activity of sulopenem was assessed against a collection from 2014 to 2016 of 539 urinary isolates ofEscherichia coli from Canadian patients by using CLSI-defined broth microdilution methodology. A concentration of sulopenem 0.03 µg/ml inhibited both 50% (MIC50 ) and 90% (MIC90 ) of isolates tested; sulopenem MICs ranged from 0.015 to 0.25 µg/ml.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research