Acquisition of Extended-Spectrum β-Lactamase GES-6 Leading to Resistance to Ceftolozane-Tazobactam Combination in Pseudomonas aeruginosa | Zendy

Laurent Poirel | Zendy; José Manuel Ortiz de la Rosa | Zendy; Nicolas Kieffer | Zendy; Véronique Dubois | Zendy; Aurélie Jayol | Zendy; Patrice Nordmann | Zendy

Open Access

Acquisition of Extended-Spectrum β-Lactamase GES-6 Leading to Resistance to Ceftolozane-Tazobactam Combination in Pseudomonas aeruginosa

Author(s) -

Laurent Poirel,

José Manuel Ortiz de la Rosa,

Nicolas Kieffer,

Véronique Dubois,

Aurélie Jayol,

Patrice Nordmann

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01809-18

Subject(s) - pseudomonas aeruginosa , tazobactam , microbiology and biotechnology , broad spectrum , biology , chemistry , bacteria , imipenem , genetics , combinatorial chemistry

A clinical Pseudomonas aeruginosa isolate resistant to all β-lactams, including ceftolozane-tazobactam and carbapenems, was recovered. It belonged to sequence type 235 and produced the extended-spectrum β-lactamase (ESBL) GES-6 differing from GES-1 by two amino acid substitutions (E104K and G170S). GES-6 possessed an increased hydrolytic activity toward carbapenems and to ceftolozane and a decreased susceptibility to β-lactamase inhibitors compared to GES-1, except for avibactam. We show here that resistance to ceftolozane-tazobactam may occur through acquisition of a specific ESBL in P. aeruginosa but that ceftazidime-avibactam combination remains an effective alternative.

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