In Vitro Efficacy of a Novel Active-Release Antimicrobial Coating To Eradicate Biofilms of Pseudomonas aeruginosa | Zendy

Dustin L. Williams | Zendy; Julia M. Lerdahl | Zendy; Bryan S. Haymond | Zendy; Roy D. Bloebaum | Zendy

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In Vitro Efficacy of a Novel Active-Release Antimicrobial Coating To Eradicate Biofilms of Pseudomonas aeruginosa

Author(s) -

Dustin L. Williams,

Julia M. Lerdahl,

Bryan S. Haymond,

Roy D. Bloebaum

Publication year - 2014

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01798-13

Subject(s) - biofilm , pseudomonas aeruginosa , antimicrobial , microbiology and biotechnology , in vitro , coating , implant , chemistry , biology , bacteria , medicine , surgery , biochemistry , genetics , organic chemistry

Implant-related infections are becoming increasingly difficult to treat due to the formation of biofilms on implant surfaces. This study analyzed thein vitro efficacy of a novel antimicrobial coating against biofilms ofPseudomonas aeruginosa , using a flow cell system. Results indicated thatP. aeruginosa biofilms were reduced by greater than 8 log10 units in less than 24 h. Data indicated that this active-release coating may be promising for preventing biofilm implant-related infections.

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