Open AccessLongitudinal Model-Based Biomarker Analysis of Exposure-Response Relationships in Adults with Pulmonary Tuberculosis
Author(s) -
Andrew Gewitz,
Belén P Solans,
William R. Mac Kenzie,
Charles M. Heilig,
William C. Whitworth,
John L. Johnson,
Pheosubuga,
Susan E. Dorman,
Marc Weiner,
Radojka M. Savic
Publication year - 2021
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01794-20
Subject(s) - sputum , rifapentine , sputum culture , biomarker , tuberculosis , medicine , mycobacterium tuberculosis , culture conversion , surrogate endpoint , covariate , clinical endpoint , randomized controlled trial , population , regimen , oncology , biology , pathology , latent tuberculosis , biochemistry , statistics , mathematics , environmental health
The identification of sensitive, specific, and reliable biomarkers that can be quantified in the early phases of tuberculosis treatment and predictive of long-term outcome is key for the development of an effective short-course treatment regimen. Time to positivity (TTP), a biomarker of treatment outcome againstMycobacterium tuberculosis , measures longitudinal bacterial growth in mycobacterial growth indicator tube broth culture and may be predictive of standard time to stable culture conversion (TSCC).