Geno- and Phenotypic Characterization of Human Cytomegalovirus Mutants SelectedIn Vitroafter Letermovir (AIC246) Exposure | Zendy

Thomas Goldner | Zendy; Christine Hempel | Zendy; Helga RuebsamenSchaeff | Zendy; Holger Zimmermann | Zendy; Peter Lischka | Zendy

Open Access

Geno- and Phenotypic Characterization of Human Cytomegalovirus Mutants SelectedIn Vitroafter Letermovir (AIC246) Exposure

Author(s) -

Thomas Goldner,

Christine Hempel,

Helga RuebsamenSchaeff,

Holger Zimmermann,

Peter Lischka

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01794-13

Subject(s) - human cytomegalovirus , biology , cytomegalovirus , mutant , virology , phenotype , in vitro , mode of action , polymerase , mutation , protein subunit , herpesviridae , dna , virus , genetics , viral disease , gene , biochemistry

Letermovir is a novel antiviral compound currently in clinical development for the prevention of human cytomegalovirus (HCMV) infections. In contrast to all currently approved anti-HCMV drugs that target the viral DNA polymerase, letermovir acts via a distinct mode of action involving the viral terminase subunit pUL56. To extend our understanding of potential letermovir resistance mechanisms, we used marker transfer to characterize mutations identified in letermovir-resistant HCMV variants that were selected in cell culture.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research