In Vitro Responses of Acinetobacter baumannii to Two- and Three-Drug Combinations following Exposure to Colistin and Doripenem | Zendy

Louise M. Oleksiuk | Zendy; M. Hong Nguyen | Zendy; Ellen G. Press | Zendy; Cassaundra L. Updike | Zendy; Jessica A. O’Hara | Zendy; Yohei Doi | Zendy; Cornelius J. Clancy | Zendy; Ryan K. Shields | Zendy

Open Access

In Vitro Responses of Acinetobacter baumannii to Two- and Three-Drug Combinations following Exposure to Colistin and Doripenem

Author(s) -

Louise M. Oleksiuk,

M. Hong Nguyen,

Ellen G. Press,

Cassaundra L. Updike,

Jessica A. O’Hara,

Yohei Doi,

Cornelius J. Clancy,

Ryan K. Shields

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01779-13

Subject(s) - doripenem , colistin , acinetobacter baumannii , sulbactam , microbiology and biotechnology , carbapenem , acinetobacter , medicine , biology , antibiotics , pseudomonas aeruginosa , meropenem , bacteria , antibiotic resistance , imipenem , genetics

We comparedin vitro killing of colistin, doripenem, and sulbactam by time-kill methods againstAcinetobacter baumannii isolates collected from patients before and after colistin-doripenem treatment (initial and recurrent isolates, respectively). Colistin-doripenem bactericidal activity against recurrent isolates was attenuated (mean log10 kill, −5.74 versus −2.88;P = 0.01) but was restored by adding sulbactam. Doripenem MICs rather than colistin MICs correlated with the activity of colistin-doripenem. Among colistin-resistant isolates, colistin-doripenem-sulbactam combinations achieved greater killing than colistin-doripenem alone (−5.65 versus −2.43;P = 0.04).

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