Neisseria gonorrhoeae Strain with High-Level Resistance to Spectinomycin Due to a Novel Resistance Mechanism (Mutated Ribosomal Protein S5) Verified in Norway | Zendy

Magnus Unemo | Zendy; Daniel Golparian | Zendy; Vegard Skogen | Zendy; Anne O. Olsen | Zendy; Harald Moi | Zendy; Gaute Syversen | Zendy; Stig Ove Hjelmevoll | Zendy

Open Access

Neisseria gonorrhoeae Strain with High-Level Resistance to Spectinomycin Due to a Novel Resistance Mechanism (Mutated Ribosomal Protein S5) Verified in Norway

Author(s) -

Magnus Unemo,

Daniel Golparian,

Vegard Skogen,

Anne O. Olsen,

Harald Moi,

Gaute Syversen,

Stig Ove Hjelmevoll

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01775-12

Subject(s) - spectinomycin , neisseria gonorrhoeae , gonorrhea , biology , genetics , microbiology and biotechnology , ribosomal rna , ribosomal protein , antibiotic resistance , gene , ribosome , antibiotics , virology , rna , human immunodeficiency virus (hiv)

Gonorrhea may become untreatable, and new treatment options are essential. Verified resistance to spectinomycin is exceedingly rare. However, we describe a high-level spectinomycin-resistant (MIC, >1,024 μg/ml) Neisseria gonorrhoeae strain from Norway with a novel resistance mechanism. The resistance determinant was a deletion of codon 27 (valine) and a K28E alteration in the ribosomal protein 5S. The traditional spectinomycin resistance gene (16S rRNA) was wild type. Despite this exceedingly rare finding, spectinomycin available for treatment of ceftriaxone-resistant urogenital gonorrhea would be very valuable.

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