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Antimicrobial susceptibilities were determined for 1,586 isolates of Stenotrophomonas maltophilia from globally diverse medical centers using the Clinical Laboratory Standards Institute broth microdilution method. The combination trimethoprim-sulfamethoxazole (96.0% of isolates susceptible at &lt; or =2 microg/ml trimethoprim and 38 microg/ml sulfamethoxazole) and tigecycline (95.5% of isolates sussceptible at &lt; or =2 microg/ml) were the only antimicrobials tested with &gt;94% susceptibility in all regions. Susceptibility rates for other commonly used were lower than expected and varied geographically. This in vitro data supports tigecycline as a potential candidate for clinical investigations into S. maltophilia infections.

antimicrobial agents and chemotherapy

Antimicrobial Susceptibilities of a Worldwide Collection of <i>Stenotrophomonas maltophilia</i> Isolates Tested against Tigecycline and Agents Commonly Used for <i>S. maltophilia</i> Infections

Antimicrobial Susceptibilities of a Worldwide Collection of Stenotrophomonas maltophilia Isolates Tested against Tigecycline and Agents Commonly Used for S. maltophilia Infections