Open AccessIn Vitro Double and Triple Bactericidal Activities of Doripenem, Polymyxin B, and Rifampin against Multidrug-Resistant Acinetobacter baumannii , Pseudomonas aeruginosa , Klebsiella pneumoniae , and Escherichia coli
Author(s) -
Carl Urban,
Noriel Mariano,
James J. Rahal
Publication year - 2010
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01768-09
Subject(s) - doripenem , acinetobacter baumannii , microbiology and biotechnology , klebsiella pneumoniae , pseudomonas aeruginosa , polymyxin b , polymyxin , carbapenem , biology , meropenem , antibiotics , acinetobacter , multiple drug resistance , escherichia coli , bacteria , antibiotic resistance , biochemistry , genetics , gene
In vitro double and triple bactericidal activities of doripenem, polymyxin B, and rifampin were assessed against 20 carbapenem-resistant clinical isolates with different mechanisms of carbapenem resistance. Bactericidal activity was achieved in 90% of all bacteria assayed using combinations of polymyxin B, doripenem, and rifampin against five each of the carbapenem-resistantKlebsiella pneumoniae ,Acinetobacter baumannii ,Pseudomonas aeruginosa , andEscherichia coli isolates studied. Combinations with these antibacterials may provide a strategy for treatment of patients infected with such organisms.