The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop | Zendy

Antonela R. Palacios | Zendy; María F. Mojica | Zendy; Estefanía Giannini | Zendy; Magdalena A. Taracila | Zendy; Christopher R. Bethel | Zendy; Pedro M. Alzari | Zendy; Lisandro H. Otero | Zendy; Sebastián Klinke | Zendy; Leticia I. Llarrull | Zendy; Robert A. Bonomo | Zendy; Alejandro J. Vila | Zendy

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The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop

Author(s) -

Antonela R. Palacios,

María F. Mojica,

Estefanía Giannini,

Magdalena A. Taracila,

Christopher R. Bethel,

Pedro M. Alzari,

Lisandro H. Otero,

Sebastián Klinke,

Leticia I. Llarrull,

Robert A. Bonomo,

Alejandro J. Vila

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01754-18

Subject(s) - active site , loop (graph theory) , mechanism (biology) , chemistry , combinatorial chemistry , stereochemistry , biophysics , biochemistry , biology , catalysis , physics , mathematics , combinatorics , quantum mechanics

Carbapenems are “last resort” β-lactam antibiotics used to treat serious and life-threatening health care-associated infections caused by multidrug-resistant Gram-negative bacteria. Unfortunately, the worldwide spread of genes coding for carbapenemases among these bacteria is threatening these life-saving drugs.

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