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While reports ofKlebsiella pneumoniae carbapenemase (KPC) production amongPseudomonas aeruginosa strains have emerged from a number of countries worldwide, outcome data are lacking. This is the first report evaluating how KPC production inP. aeruginosa impacts the efficacy of carbapenems by using the murine thigh infection model. Our findings suggest that the impact of KPC-2in vivo is less pronounced than would be anticipated based on thein vitro potency.

KPC Presence in Pseudomonas aeruginosa Has Minimal Impact on the In Vivo Efficacy of Carbapenem Therapy