A Clonal Complex 12 Methicillin-Resistant Staphylococcus aureus Strain, West Australian MRSA-59, Harbors a Novel Pseudo-SCC mec Element | Zendy

Stefan Monecke | Zendy; Geoffrey W. Coombs | Zendy; Julie Pearson | Zendy; Helmut Hotzel | Zendy; Peter Slickers | Zendy; Ralf Ehricht | Zendy

Open Access

A Clonal Complex 12 Methicillin-Resistant Staphylococcus aureus Strain, West Australian MRSA-59, Harbors a Novel Pseudo-SCC mec Element

Author(s) -

Stefan Monecke,

Geoffrey W. Coombs,

Julie Pearson,

Helmut Hotzel,

Peter Slickers,

Ralf Ehricht

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01745-15

Subject(s) - staphylococcus aureus , microbiology and biotechnology , biology , strain (injury) , methicillin resistant staphylococcus aureus , mobile genetic elements , gene , genetics , plasmid , bacteria , anatomy

A West Australian methicillin-resistant Staphylococcus aureus strain (WA MRSA-59) was characterized by microarray and sequencing. Its pseudo-staphylococcal cassette chromosome mec (SCCmec) element comprised dcs, Q9XB68-dcs, mvaS-SCC, Q5HJW6, dru, ugpQ, ydeM, mecA-mecR-mecI, txbi mecI, tnp IS431, copA2-mco (copper resistance), ydhK, arsC-arsB-arsR (arsenic resistance), open reading frame PT43, and per-2. Recombinase genes, xylR (mecR2), and PSM-mec (phenol-soluble modulin) were absent. We suggest that mec complex A should be split into two subtypes. One harbors PSM-mec and xylR (mecR2). It is found in SCCmec types II, III, and VIII. The second subtype, described herein, is present in WA MRSA-59 and some coagulase-negative staphylococci.

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