Inhibitors of Signaling Pathways That Block Reversal of HIV-1 Latency | Zendy

Benni Vargas | Zendy; Nicholas S. Giacobbi | Zendy; Anwesha Sanyal | Zendy; Narasimhan J. Venkatachari | Zendy; Feng Han | Zendy; Phalguni Gupta | Zendy; Nicolas SluisCremer | Zendy

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Inhibitors of Signaling Pathways That Block Reversal of HIV-1 Latency

Author(s) -

Benni Vargas,

Nicholas S. Giacobbi,

Anwesha Sanyal,

Narasimhan J. Venkatachari,

Feng Han,

Phalguni Gupta,

Nicolas SluisCremer

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01744-18

Subject(s) - kinase , signal transduction , latency (audio) , panobinostat , biology , cell culture , chemistry , microbiology and biotechnology , biochemistry , gene , genetics , histone deacetylase , electrical engineering , histone , engineering

Signaling pathways play a key role in HIV-1 latency. In this study, we used the 24ST1NLESG cell line of HIV-1 latency to screen a library of structurally diverse, medicinally active, cell permeable kinase inhibitors, which target a wide range of signaling pathways, to identify inhibitors of HIV-1 latency reversal.

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