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Glycopeptides such as vancomycin have been used as the first-line therapy against MRSA infections for over half a century. Reduced susceptibility and emergence of resistance to first-generation glycopeptides has led to development of second-generation lipoglycopeptide derivatives such as dalbavancin which hold broader ranges of activity and enhanced pharmacokinetic properties.

antimicrobial agents and chemotherapy

Dalbavancin Alone and in Combination with Ceftaroline against Four Different Phenotypes of <i>Staphylococcus aureus</i> in a Simulated Pharmacodynamic/Pharmacokinetic Model

Dalbavancin Alone and in Combination with Ceftaroline against Four Different Phenotypes of Staphylococcus aureus in a Simulated Pharmacodynamic/Pharmacokinetic Model