In Vitro Activity of Novel Gyrase Inhibitors against a Highly Resistant Population of Pseudomonas aeruginosa | Zendy

Pamela R. Tessier | Zendy; David P. Nicolau | Zendy

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In Vitro Activity of Novel Gyrase Inhibitors against a Highly Resistant Population of Pseudomonas aeruginosa

Author(s) -

Pamela R. Tessier,

David P. Nicolau

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01740-12

Subject(s) - dna gyrase , pseudomonas aeruginosa , microbiology and biotechnology , minimum inhibitory concentration , multiple drug resistance , ofloxacin , population , in vitro , biology , ciprofloxacin , drug resistance , antibiotics , medicine , bacteria , escherichia coli , genetics , gene , environmental health

The activity of five novel gyrase inhibitors was evaluated against 303 nonduplicate Pseudomonas aeruginosa strains collected from 53 North American institutions. The most active compound, GP-2, displayed MIC(50) and MIC(90) values of 1 and 2 μg/ml, respectively. Cross-resistance to other commercially available antipseudomonal compounds was not evident, as no major change was observed in the gyrase inhibitor MIC distribution when stratified by nonsusceptible phenotypes, including the fluoroquinolones and those isolates classified as multidrug resistant (MDR).

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