Inhibition of Cytomegalovirus Replication with Extended-Half-Life Synthetic Ozonides | Zendy

Yiping Wang | Zendy; Rupkatha Mukhopadhyay | Zendy; Sujayita Roy | Zendy; Arun Kapoor | Zendy; YuPing Su | Zendy; Susan A. Charman | Zendy; Gong� Chen | Zendy; Jianbo Wu | Zendy; Xiaofang Wang | Zendy; Jonathan L. Vennerstrom | Zendy; Ravit AravBoger | Zendy

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Inhibition of Cytomegalovirus Replication with Extended-Half-Life Synthetic Ozonides

Author(s) -

Yiping Wang,

Rupkatha Mukhopadhyay,

Sujayita Roy,

Arun Kapoor,

YuPing Su,

Susan A. Charman,

Gong� Chen,

Jianbo Wu,

Xiaofang Wang,

Jonathan L. Vennerstrom,

Ravit AravBoger

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01735-18

Subject(s) - human cytomegalovirus , ganciclovir , in vivo , artesunate , pharmacology , artemisinin , in vitro , cell growth , biology , pharmacokinetics , viral replication , chemistry , virology , virus , plasmodium falciparum , immunology , biochemistry , malaria , microbiology and biotechnology

Artesunate (AS), a semisynthetic artemisinin approved for malaria therapy, inhibits human cytomegalovirus (HCMV) replicationin vitro , but therapeutic success in humans has been variable. We hypothesized that the shortin vivo half-life of AS may contribute to the different treatment outcomes.

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