In Vitro Activities of Omadacycline (PTK 0796) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas | Zendy

Ken B. Waites | Zendy; Donna M. Crabb | Zendy; Yang Liu | Zendy; Lynn B. Duffy | Zendy

Open Access

In Vitro Activities of Omadacycline (PTK 0796) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas

Author(s) -

Ken B. Waites,

Donna M. Crabb,

Yang Liu,

Lynn B. Duffy

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01734-16

Subject(s) - mycoplasma hominis , ureaplasma , moxifloxacin , tetracycline , microbiology and biotechnology , antimicrobial , mycoplasma , doxycycline , ureaplasma urealyticum , azithromycin , chemistry , biology , antibiotics

In vitro activities of omadacycline, a new aminomethylcycline, were determined forMycoplasma andUreaplasma spp. and compared with those of azithromycin, clindamycin, moxifloxacin, tetracycline, and doxycycline. All omadacycline MICs were <2 μg/ml. MIC90 s were 0.063 μg/ml forMycoplasma hominis , 0.25 μg/ml forMycoplasma pneumoniae , and 2 μg/ml forUreaplasma spp. Omadacycline had the lowest MIC90 among all drugs tested againstM. hominis . Omadacycline activity was not affected by macrolide, tetracycline, or fluoroquinolone resistance.

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