Open AccessInsertion Sequence IS Aba11 Is Involved in Colistin Resistance and Loss of Lipopolysaccharide in Acinetobacter baumannii
Author(s) -
Jennifer H. Moffatt,
Marina Harper,
Ben Adler,
Roger L. Nation,
Jian Li,
John D. Boyce
Publication year - 2011
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01732-10
Subject(s) - acinetobacter baumannii , colistin , lipid a , microbiology and biotechnology , insertion sequence , lipopolysaccharide , biology , sequence (biology) , gene , multiple drug resistance , polymyxin , antibiotics , bacteria , genetics , pseudomonas aeruginosa , immunology , genome , transposable element
Infections caused byAcinetobacter baumannii are of increasing concern, largely due to the multidrug resistance of many strains. Here we show that insertion sequence ISAba11 movement can result in inactivation of theA. baumannii lipid A biosynthesis geneslpxA andlpxC , resulting in the complete loss of lipopolysaccharide production and high-level colistin resistance.