Effects of Food and Omeprazole on a Novel Formulation of Super Bioavailability Itraconazole in Healthy Subjects | Zendy

Julian Lindsay | Zendy; Stuart Mudge | Zendy; George R. Thompson | Zendy

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Effects of Food and Omeprazole on a Novel Formulation of Super Bioavailability Itraconazole in Healthy Subjects

Author(s) -

Julian Lindsay,

Stuart Mudge,

George R. Thompson

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01723-18

Subject(s) - bioavailability , itraconazole , pharmacokinetics , crossover study , pharmacology , omeprazole , oral administration , meal , dosing , medicine , cmax , chemistry , antifungal , alternative medicine , pathology , dermatology , placebo

To address the limited bioavailability and intolerance of the conventional itraconazole (ITZ) formulations, a new formulation labeledsu perb ioa vailability (SUBA) itraconazole has been developed; however, the specific effects of food and gastric pH are unknown. This study evaluated the pharmacokinetic profile of SUBA itraconazole under fasting and fed conditions, as well as with the concomitant administration of a proton pump inhibitor.

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