Oral Tobramycin Prophylaxis Prior to Colorectal Surgery Is Not Associated with Systemic Uptake | Zendy

Tessa Mulder | Zendy; Marjolein Kluytmans-van den Bergh | Zendy; Rogier M. P. H. Crolla | Zendy; Anton A. M. Ermens | Zendy; Jannie Romme | Zendy; Nils E. van’t Veer | Zendy; Jan Kluytmans | Zendy

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Oral Tobramycin Prophylaxis Prior to Colorectal Surgery Is Not Associated with Systemic Uptake

Author(s) -

Tessa Mulder,

Marjolein Kluytmans-van den Bergh,

Rogier M. P. H. Crolla,

Anton A. M. Ermens,

Jannie Romme,

Nils E. van’t Veer,

Jan Kluytmans

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01723-17

Subject(s) - tobramycin , medicine , colistin , antibiotics , antibiotic prophylaxis , prospective cohort study , colorectal surgery , toxicity , liter , chemoprophylaxis , surgery , anesthesia , gastroenterology , abdominal surgery , gentamicin , microbiology and biotechnology , biology

Preoperative oral prophylaxis with nonabsorbable antibiotics has been reported to reduce the risk of surgical site infections after colorectal surgery. This prospective study was conducted to evaluate the risk of toxic side effects by measuring postoperative serum tobramycin levels in patients who received a 3-day prophylaxis with tobramycin and colistin prior to colorectal surgery. In all patients, serum tobramycin concentrations were below the detection limit (0.3 mg/liter), implying a low risk of toxicity.

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