Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression | Zendy

Srijan Ranjitkar | Zendy; Adriana K. Jones | Zendy; Mina Mostafavi | Zendy; Zachary Zwirko | Zendy; Oleg Iartchouk | Zendy; S. Whitney Barnes | Zendy; John R. Walker | Zendy; Thomas Willis | Zendy; Patrick S. Lee | Zendy; Charles R. Dean | Zendy

Open Access

Target (MexB)- and Efflux-Based Mechanisms Decreasing the Effectiveness of the Efflux Pump Inhibitor D13-9001 in Pseudomonas aeruginosa PAO1: Uncovering a New Role for MexMN-OprM in Efflux of β-Lactams and a Novel Regulatory Circuit (MmnRS) Controlling MexMN Expression

Author(s) -

Srijan Ranjitkar,

Adriana K. Jones,

Mina Mostafavi,

Zachary Zwirko,

Oleg Iartchouk,

S. Whitney Barnes,

John R. Walker,

Thomas Willis,

Patrick S. Lee,

Charles R. Dean

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01718-18

Subject(s) - efflux , pseudomonas aeruginosa , antibiotics , microbiology and biotechnology , chemistry , biology , bacteria , biochemistry , genetics

Efflux pumps contribute to antibiotic resistance in Gram-negative pathogens. Correspondingly, efflux pump inhibitors (EPIs) may reverse this resistance.

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