Pharmacokinetics and Ex Vivo Pharmacodynamic Antimalarial Activity of Dihydroartemisinin-Piperaquine in Patients with Uncomplicated Falciparum Malaria in Vietnam | Zendy

Dao Van Hoang Nguyen | Zendy; Quoc P. Nguyen | Zendy; Ngoa Dang Nguyen | Zendy; Thuy Thi Le | Zendy; The Duy Nguyen | Zendy; Duy Ngoc Dinh | Zendy; Thanh Xuân Nguyễn | Zendy; Bui Dai | Zendy; Marina Chavchich | Zendy; Michael D. Edstein | Zendy

Open Access

Pharmacokinetics and Ex Vivo Pharmacodynamic Antimalarial Activity of Dihydroartemisinin-Piperaquine in Patients with Uncomplicated Falciparum Malaria in Vietnam

Author(s) -

Dao Van Hoang Nguyen,

Quoc P. Nguyen,

Ngoa Dang Nguyen,

Thuy Thi Le,

The Duy Nguyen,

Duy Ngoc Dinh,

Thanh Xuân Nguyễn,

Bui Dai,

Marina Chavchich,

Michael D. Edstein

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01717-08

Subject(s) - dihydroartemisinin , piperaquine , malaria , pharmacokinetics , pharmacology , medicine , plasmodium falciparum , pharmacodynamics , ex vivo , artemisinin , in vivo , biology , immunology , microbiology and biotechnology

Compared to healthy subjects, malaria patients show a reduction in the mean oral clearance (1.19 versus 5.87 liters/h/kg of body weight) and apparent volume of distribution (1.47 versus 8.02 liters/kg) of dihydroartemisinin in Vietnamese patients following treatment with dihydroartemisinin-piperaquine (Artekin) for uncomplicated Plasmodium falciparum. Dihydroartemisinin is responsible for most of the ex vivo antimalarial activity of dihydroartemisinin-piperaquine.

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