Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice | Zendy

Franck Amblard | Zendy; Sébastien Bouclé | Zendy; Leda Bassit | Zendy; Bryan D. Cox | Zendy; Ozkan Sari | Zendy; Sijia Tao | Zendy; Zhe Chen | Zendy; Tuğba Öztürk | Zendy; Kiran Verma | Zendy; Olivia Ollinger Russell | Zendy; Virgile Rat | Zendy; Hugues de Rocquigny | Zendy; Oriane Fiquet | Zendy; Maud Boussand | Zendy; James P. Di Santo | Zendy; Hélène StrickMarchand | Zendy; Raymond F. Schinazi | Zendy

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Novel Hepatitis B Virus Capsid Assembly Modulator Induces Potent Antiviral Responses In Vitro and in Humanized Mice

Author(s) -

Franck Amblard,

Sébastien Bouclé,

Leda Bassit,

Bryan D. Cox,

Ozkan Sari,

Sijia Tao,

Zhe Chen,

Tuğba Öztürk,

Kiran Verma,

Olivia Ollinger Russell,

Virgile Rat,

Hugues de Rocquigny,

Oriane Fiquet,

Maud Boussand,

James P. Di Santo,

Hélène StrickMarchand,

Raymond F. Schinazi

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01701-19

Subject(s) - capsid , virology , in vitro , hepatitis b virus , humanized mouse , virus , biology , in vivo , biochemistry , microbiology and biotechnology

Hepatitis B virus (HBV) affects an estimated 250 million chronic carriers worldwide. Though several vaccines exist, they are ineffective for those already infected. HBV persists due to the formation of covalently closed circular DNA (cccDNA)—the viral minichromosome—in the nucleus of hepatocytes. Current nucleoside analogs and interferon therapies rarely clear cccDNA, requiring lifelong treatment.

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