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Ibrexafungerp is a first-in-class glucan synthase inhibitor.In vitro activity was determined for 89Candida glabrata isolates with molecularly identifiedFKS1 orFKS2 mutations conferring resistance to the echinocandins. All isolates were resistant to at least one echinocandin (i.e., anidulafungin, caspofungin, or micafungin) by broth microdilution. Results for ibrexafungerp were compared with those for each echinocandin.

In Vitro Activity of Ibrexafungerp, a Novel Glucan Synthase Inhibitor against Candida glabrata Isolates with FKS Mutations