Antibiotic Resistance Genes in the Bacteriophage DNA Fraction of Human Fecal Samples | Zendy

Pablo Quirós | Zendy; Marta Colomer-Lluch | Zendy; Alexandre MartínezCastillo | Zendy; Elisenda Miró | Zendy; M. Pilar Argente | Zendy; Juan Jofre | Zendy; Ferrán Navarro | Zendy; Maite Muniesa | Zendy

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Antibiotic Resistance Genes in the Bacteriophage DNA Fraction of Human Fecal Samples

Author(s) -

Pablo Quirós,

Marta Colomer-Lluch,

Alexandre MartínezCastillo,

Elisenda Miró,

M. Pilar Argente,

Juan Jofre,

Ferrán Navarro,

Maite Muniesa

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01684-13

Subject(s) - bacteriophage , feces , biology , dna , microbiology and biotechnology , antibiotics , gene , antibiotic resistance , bacteria , genetics , escherichia coli

A group of antibiotic resistance genes (ARGs) (blaTEM, blaCTX-M-1, mecA, armA, qnrA, and qnrS) were analyzed by real-time quantitative PCR (qPCR) in bacteriophage DNA isolated from feces from 80 healthy humans. Seventy-seven percent of the samples were positive in phage DNA for one or more ARGs. blaTEM, qnrA, and, blaCTX-M-1 were the most abundant, and armA, qnrS, and mecA were less prevalent. Free bacteriophages carrying ARGs may contribute to the mobilization of ARGs in intra- and extraintestinal environments.

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