Antimicrobial Susceptibility of Mycoplasma pneumoniae Isolates and Molecular Analysis of Macrolide-Resistant Strains from Shanghai, China | Zendy

Yang Liu | Zendy; Xinyu Ye | Zendy; Hong Zhang | Zendy; Xiaogang Xu | Zendy; Wanhua Li | Zendy; Demei Zhu | Zendy; Minggui Wang | Zendy

Open Access

Antimicrobial Susceptibility of Mycoplasma pneumoniae Isolates and Molecular Analysis of Macrolide-Resistant Strains from Shanghai, China

Author(s) -

Yang Liu,

Xinyu Ye,

Hong Zhang,

Xiaogang Xu,

Wanhua Li,

Demei Zhu,

Minggui Wang

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01684-08

Subject(s) - mycoplasma pneumoniae , microbiology and biotechnology , macrolide antibiotics , biology , antimicrobial , klebsiella pneumoniae , mycoplasma , virology , antibacterial agent , antibiotics , erythromycin , medicine , genetics , gene , pneumonia , escherichia coli

Fifty-threeMycoplasma pneumoniae strains were isolated from pediatric patients in Shanghai, China, from October 2005 to February 2008. Of 53 clinical isolates, 44 (83%) were resistant to erythromycin (MICs of >128 μg/ml for all 44 strains), azithromycin, and clarithromycin. All macrolide-resistantM. pneumoniae strains harbored an A-to-G transition mutation at position 2063 in 23S rRNA genes. Forty-five (85%) clinical isolates were classified into the P1 gene restriction fragment length polymorphism type I, and six (11%) were type II.

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