In Vitro Susceptibility of Mycobacterium tuberculosis to Trimethoprim and Sulfonamides in France | Zendy

Sirwan Muhammed Ameen | Zendy; Michel Drancourt | Zendy

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In Vitro Susceptibility of Mycobacterium tuberculosis to Trimethoprim and Sulfonamides in France

Author(s) -

Sirwan Muhammed Ameen,

Michel Drancourt

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01683-13

Subject(s) - microbiology and biotechnology , mycobacterium tuberculosis , trimethoprim , tuberculosis , in vitro , sulfamethoxazole , antibacterial agent , antibiotics , virology , biology , medicine , genetics , pathology

Five type strains and 55Mycobacterium tuberculosis complex clinical isolates were found resistant to trimethoprim with a MIC of >200 mg/liter and susceptible to both sulfadiazine and cotrimoxazole with a MIC90 of 10 mg/liter. TwoM. canettii isolates uniquely yielded silent mutations C156 → T and G238 → C in thefolP1 gene. Combined with scarce published data, these data indicate that sulfamides could be considered alternative antituberculous antibiotics.

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