Open AccessAntifungal Therapy in an Athymic Murine Model of Chromoblastomycosis by Fonsecaea pedrosoi
Author(s) -
Enrique Calvo,
Francisco Pastor,
Emilio Mayayo,
Pilar Hernández,
Josep Guarro
Publication year - 2011
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01662-10
Subject(s) - chromoblastomycosis , itraconazole , terbinafine , posaconazole , voriconazole , biology , mycosis , medicine , microbiology and biotechnology , antifungal , pharmacology , immunology
We have compared the efficacy of terbinafine (TRB) and itraconazole (ITZ), the recommended drugs for the treatment of chromoblastomycosis, with that of posaconazole (PSC) and voriconazole (VRC) in athymic mice infected with the fungusFonsecaea pedrosoi . Three weeks after challenge, mice were treated for 4 months with PSC at 10 or 20 mg/kg of body weight/day, with VRC at 10 or 20 mg/kg/day, with ITZ at 25 or 50 mg/kg/day, or with TRB at 150 or 250 mg/kg/day. The progress of the infection was evaluated by measuring the size of the lesions, by histopathological studies, and by cultures of the excised tissue. The two doses of PSC followed by the highest doses of ITZ and TRB showed the best results while VRC did not show efficacy. PSC could be an alternative in the treatment of chromoblastomycosis.