Reduced Biocide Susceptibility in Candida albicans Biofilms
Author(s) -
Jeniel E. Nett,
Kristie M. Guite,
Alex Ringeisen,
Kathleen A. Holoyda,
David R. Andes
Publication year - 2008
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01656-07
Subject(s) - biocide , candida albicans , biofilm , microbiology and biotechnology , biology , bacteria , chemistry , genetics , organic chemistry
Candida biofilm formation is common during infection and environmental growth. We tested the impacts of three biocides (ethanol [EtOH], H(2)O(2), and sodium dodecyl sulfate) on Candida albicans, C. parapsilosis, and C. glabrata biofilms. Higher concentrations of the biocides were required for efficacy against biofilms than for efficacy against planktonic controls. A combination study with two biocides (EtOH and H(2)O(2)) and fluconazole demonstrated that the combination had enhanced efficacy.
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