A Hyperactive Form of the Zinc Cluster Transcription Factor Stb5 Causes YOR1 Overexpression and Beauvericin Resistance in Candida albicans | Zendy

Bernardo RamírezZavala | Zendy; Hannah Manz | Zendy; Frank Englert | Zendy; P. David Rogers | Zendy; Joachim Morschhäuser | Zendy

Open Access

A Hyperactive Form of the Zinc Cluster Transcription Factor Stb5 Causes YOR1 Overexpression and Beauvericin Resistance in Candida albicans

Author(s) -

Bernardo RamírezZavala,

Hannah Manz,

Frank Englert,

P. David Rogers,

Joachim Morschhäuser

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01655-18

Subject(s) - beauvericin , candida albicans , efflux , corpus albicans , microbiology and biotechnology , biology , atp binding cassette transporter , fluconazole , transcription factor , chemistry , gene , genetics , transporter , antifungal , fusarium

Gain-of-function mutations in the zinc cluster transcription factors Mrr1, Tac1, and Upc2, which result in constitutive overexpression of their target genes, are a frequent cause of fluconazole resistance in the pathogenic yeastCandida albicans . In this study, we show that an activated form of another zinc cluster transcription factor, Stb5, confers resistance to the natural compound beauvericin via the overexpression ofYOR1 , encoding an efflux pump of the ATP-binding cassette transporter superfamily.

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