A Novel erm (44) Gene Variant from a Human Staphylococcus saprophyticus Isolate Confers Resistance to Macrolides and Lincosamides but Not Streptogramins | Zendy

Christian Strauß | Zendy; Yanmin Hu | Zendy; Anthony Coates | Zendy; Vincent Perreten | Zendy

Open Access

A Novel erm (44) Gene Variant from a Human Staphylococcus saprophyticus Isolate Confers Resistance to Macrolides and Lincosamides but Not Streptogramins

Author(s) -

Christian Strauß,

Yanmin Hu,

Anthony Coates,

Vincent Perreten

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01655-16

Subject(s) - lincosamides , staphylococcus saprophyticus , biology , gene , genetics , chromosome , staphylococcus aureus , staphylococcus , microbiology and biotechnology , whole genome sequencing , genome , bacteria

A novelerm (44) gene variant,erm (44)v , has been identified by whole-genome sequencing in aStaphylococcus saprophyticus isolate from the skin of a healthy person. It has the particularity to confer resistance to macrolides and lincosamides but not to streptogramin B when expressed inS. aureus . Theerm (44)v gene resides on a 19,400-bp genomic island which contains phage-associated proteins and is integrated into the chromosome ofS. saprophyticus .

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