Race/Ethnicity and Protease Inhibitor Use Influence Plasma Tenofovir Exposure in Adults Living with HIV-1 in AIDS Clinical Trials Group Study A5202 | Zendy

Cindy J. Bednasz | Zendy; Charles S. Venuto | Zendy; Qing Ma | Zendy; Eric S. Daar | Zendy; Paul E. Sax | Zendy; Margaret A. Fischl | Zendy; Ann C. Collier | Zendy; Kimberly Y. Smith | Zendy; Camlin Tierney | Zendy; Edward P. Acosta | Zendy; Donald E. Mager | Zendy; Gene D. Morse | Zendy; Héctor Hernando Villamil Bolívar | Zendy; Sandra Navarro | Zendy; Susan L. Koletar | Zendy; Diane Gochnour | Zendy; Edward Seefried | Zendy; Julie Hoffman | Zendy; Judith Feinberg | Zendy; Michelle Saemann | Zendy; Kristine B. Patterson | Zendy; Donna Pittard | Zendy; D. Currin | Zendy; Kerry Upton | Zendy; Michael S. Saag | Zendy; Graham Ray | Zendy; Steven C. Johnson | Zendy; Bartolo Santos | Zendy; C. Funk | Zendy; Michael C. Morgan | Zendy; Brenda Jackson | Zendy; Pablo Tebas | Zendy; Aleshia Thomas | Zendy; Ge-Youl Kim | Zendy; Michael K. Klebert | Zendy; Jorge Santana | Zendy; S. Marrero | Zendy; Jane Norris | Zendy; Sandra Costa Valle | Zendy; Gary M. Cox | Zendy; Martha Silberman | Zendy; Sadia Shaik | Zendy; Ruben Lopez | Zendy; Margie Vasquez | Zendy; Demetre Daskalakis | Zendy; Christina Megill | Zendy; Todd Stroberg | Zendy; Jessica Shore | Zendy; Babafemi Taiwo | Zendy; Mitchell Goldman | Zendy; Molly Boston | Zendy; Jeffrey L. Lennox | Zendy; Carlos del Río | Zendy; Timothy W. Lane | Zendy; Kim Epperson | Zendy; Annie Luetkemeyer | Zendy; Mary Payne | Zendy; Barbara Gripshover | Zendy; Dawn Antosh | Zendy; Jane Reid | Zendy; Mary Beth Adams | Zendy; Sheryl S. Storey | Zendy; Shelia B. Dunaway | Zendy; Joel E. Gallant | Zendy; Ilene Wiggins | Zendy; J. A. Swiatek | Zendy; Joseph Timpone | Zendy; Princy Kumar | Zendy; Ardis Moe | Zendy; Maria Palmer | Zendy; Jon A Gothing | Zendy; Joanne Delaney | Zendy; Kim Whitely | Zendy; Ann Marie Anderson | Zendy; Scott M. Hammer | Zendy; Michael T. Yin | Zendy; Mamta K. Jain | Zendy; Tianna Petersen | Zendy; Roberto Corales | Zendy; Christine Hurley | Zendy; Keith Henry | Zendy; B. Bordenave | Zendy; Amanda Youmans | Zendy; Mary Albrecht | Zendy; Richard B. Pollard | Zendy; Abimbola O Olusanya | Zendy; Paul R. Skolnik | Zendy; Betsy Adams | Zendy; Karen T. Tashima | Zendy; Helen Patterson | Zendy; Michelle Ukwu | Zendy; Lauren Rogers | Zendy; Henry H. Balfour | Zendy; Kathy A. Fox | Zendy; Susan Swindells | Zendy; F. Van Meter | Zendy; Gregory K. Robbins | Zendy; Nicole Burgett-Yandow | Zendy; Charles E. Davis | Zendy; Colleen Boyce | Zendy; William A. O’Brien | Zendy; Gerianne Casey | Zendy; C.-B. Hsaio | Zendy; Jeffery L. Meier | Zendy; Jack T. Stapleton | Zendy; Donna Mildvan | Zendy; Manuel Revuelta | Zendy; Wafaa ElSadr | Zendy; Avelino Loquere | Zendy; Nyef El-Daher | Zendy; T. Johnson | Zendy; Robert Gross | Zendy; Kathyrn Maffei | Zendy; Valery Hughes | Zendy; Glenn Sturge | Zendy; Deborah McMahon | Zendy; B. Rutecki | Zendy; Michael Wulfsohn | Zendy; Andrew Cheng | Zendy; Norbert Bischofberger | Zendy; Lynn P. Dix | Zendy; Qiming Liao | Zendy

Open Access

Race/Ethnicity and Protease Inhibitor Use Influence Plasma Tenofovir Exposure in Adults Living with HIV-1 in AIDS Clinical Trials Group Study A5202

Author(s) -

Cindy J. Bednasz,

Charles S. Venuto,

Qing Ma,

Eric S. Daar,

Paul E. Sax,

Margaret A. Fischl,

Ann C. Collier,

Kimberly Y. Smith,

Camlin Tierney,

Edward P. Acosta,

Donald E. Mager,

Gene D. Morse,

Héctor Hernando Villamil Bolívar,

Sandra Navarro,

Susan L. Koletar,

Diane Gochnour,

Edward Seefried,

Julie Hoffman,

Judith Feinberg,

Michelle Saemann,

Kristine B. Patterson,

Donna Pittard,

D. Currin,

Kerry Upton,

Michael S. Saag,

Graham Ray,

Steven C. Johnson,

Bartolo Santos,

C. Funk,

Michael C. Morgan,

Brenda Jackson,

Pablo Tebas,

Aleshia Thomas,

Ge-Youl Kim,

Michael K. Klebert,

Jorge Santana,

S. Marrero,

Jane Norris,

Sandra Costa Valle,

Gary M. Cox,

Martha Silberman,

Sadia Shaik,

Ruben Lopez,

Margie Vasquez,

Demetre Daskalakis,

Christina Megill,

Todd Stroberg,

Jessica Shore,

Babafemi Taiwo,

Mitchell Goldman,

Molly Boston,

Jeffrey L. Lennox,

Carlos del Río,

Timothy W. Lane,

Kim Epperson,

Annie Luetkemeyer,

Mary Payne,

Barbara Gripshover,

Dawn Antosh,

Jane Reid,

Mary Beth Adams,

Sheryl S. Storey,

Shelia B. Dunaway,

Joel E. Gallant,

Ilene Wiggins,

J. A. Swiatek,

Joseph Timpone,

Princy Kumar,

Ardis Moe,

Maria Palmer,

Jon A Gothing,

Joanne Delaney,

Kim Whitely,

Ann Marie Anderson,

Scott M. Hammer,

Michael T. Yin,

Mamta K. Jain,

Tianna Petersen,

Roberto Corales,

Christine Hurley,

Keith Henry,

B. Bordenave,

Amanda Youmans,

Mary Albrecht,

Richard B. Pollard,

Abimbola O Olusanya,

Paul R. Skolnik,

Betsy Adams,

Karen T. Tashima,

Helen Patterson,

Michelle Ukwu,

Lauren Rogers,

Henry H. Balfour,

Kathy A. Fox,

Susan Swindells,

F. Van Meter,

Gregory K. Robbins,

Nicole Burgett-Yandow,

Charles E. Davis,

Colleen Boyce,

William A. O’Brien,

Gerianne Casey,

C.-B. Hsaio,

Jeffery L. Meier,

Jack T. Stapleton,

Donna Mildvan,

Manuel Revuelta,

Wafaa ElSadr,

Avelino Loquere,

Nyef El-Daher,

T. Johnson,

Robert Gross,

Kathyrn Maffei,

Valery Hughes,

Glenn Sturge,

Deborah McMahon,

B. Rutecki,

Michael Wulfsohn,

Andrew Cheng,

Norbert Bischofberger,

Lynn P. Dix,

Qiming Liao

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01638-18

Subject(s) - protease inhibitor (pharmacology) , tenofovir , ethnic group , human immunodeficiency virus (hiv) , race (biology) , medicine , protease , pharmacology , virology , antiretroviral therapy , biology , viral load , enzyme , biochemistry , botany , sociology , anthropology

AIDS Clinical Trial Group study A5202 (ClinicalTrials.gov identifier NCT00118898) was a phase 3b, randomized, partially blinded equivalence study of open-label atazanavir/ritonavir or efavirenz, plus either placebo-controlled tenofovir disoproxil fumarate/emtricitabine or abacavir/lamivudine, in treatment-naive adults living with HIV-1, evaluating efficacy, safety, and tolerability. We report an analysis of the contribution of participant characteristics to the disposition of tenofovir plasma concentrations.

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