Influence of Recombination on Development of Mutational Resistance to Linezolid in Enterococcus faecalis JH2-2 | Zendy

Leyla Boumghar-Bourtchaï | Zendy; Anne Dhalluin | Zendy; Brigitte Malbruny | Zendy; Sébastien Galopin | Zendy; Roland Leclercq | Zendy

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Influence of Recombination on Development of Mutational Resistance to Linezolid in Enterococcus faecalis JH2-2

Author(s) -

Leyla Boumghar-Bourtchaï,

Anne Dhalluin,

Brigitte Malbruny,

Sébastien Galopin,

Roland Leclercq

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01633-08

Subject(s) - enterococcus faecalis , linezolid , genetics , biology , mutation , enterococcus , strain (injury) , recombination , microbiology and biotechnology , streptococcaceae , gene , bacteria , vancomycin , staphylococcus aureus , escherichia coli , anatomy

We compared the propensities of Enterococcus faecalis JH2-2 and of the recombination-deficient JH2-2 recA strain to develop mutational resistance to linezolid. In both organisms, a mutation in a single rrl copy conferred resistance to linezolid. Delay in acquisition of the mutation by other rrl copies in JH2-2 recA showed that gene conversion contributed to the acquisition of resistance.

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