Amphotericin B Penetrates into the Central Nervous System through Focal Disruption of the Blood-Brain Barrier in Experimental Hematogenous Candida Meningoencephalitis | Zendy

Vidmantas Petraitis | Zendy; Rūta Petraitienė | Zendy; Jessica M. Valdez | Zendy; Vasilios Pyrgos | Zendy; Martin J. Lizak | Zendy; Brenda Klaunberg | Zendy; Darius Kalasauskas | Zendy; Algidas Basevičius | Zendy; John Bacher | Zendy; Daniel K. Benjamin | Zendy; William Hope | Zendy; Thomas J. Walsh | Zendy

Open Access

Amphotericin B Penetrates into the Central Nervous System through Focal Disruption of the Blood-Brain Barrier in Experimental Hematogenous Candida Meningoencephalitis

Author(s) -

Vidmantas Petraitis,

Rūta Petraitienė,

Jessica M. Valdez,

Vasilios Pyrgos,

Martin J. Lizak,

Brenda Klaunberg,

Darius Kalasauskas,

Algidas Basevičius,

John Bacher,

Daniel K. Benjamin,

William Hope,

Thomas J. Walsh

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.01626-19

Subject(s) - candida albicans , meningoencephalitis , in vivo , blood–brain barrier , cerebrospinal fluid , amphotericin b , pathology , evans blue , in vitro , central nervous system , bolus (digestion) , medicine , biology , microbiology and biotechnology , surgery , antifungal , biochemistry

HematogenousCandida meningoencephalitis (HCME) is a life-threatening complication of neonates and immunocompromised children. Amphotericin B (AmB) shows poor permeation and low cerebrospinal fluid (CSF) concentrations but is effective in the treatment of HCME. In order to better understand the mechanism of CNS penetration of AmB, we hypothesized that AmB may achieve focally higher concentrations in infected CNS lesions.

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