Open AccessNovel Chromosome-Encoded CTX-M-78 β-Lactamase from a Kluyvera georgiana Clinical Isolate as a Putative Origin of CTX-M-25 Subgroup
Author(s) -
María Margarita Rodríguez,
Pablo Power,
Hélio S. Sader,
Moreno Galleni,
Gabriel Gutkind
Publication year - 2010
Publication title -
antimicrobial agents and chemotherapy
Language(s) - Spanish
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01615-09
Subject(s) - biology , genetics , microbiology and biotechnology
While TEM- and SHV-derived extended-spectrum β-lactamases (ESBLs) arose by point mutations in genes encoding broad-spectrum variants that were extensively disseminated into mobile elements, CTX-M β-lactamases are derived from natural (chromosomal) counterparts that already have oxyimino-cephalosporinase activity.Fil: Rodríguez, María Margarita. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Power, Pablo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sader, Helio. JMI Laboratories; Estados UnidosFil: Galleni, Moreno. Universite de Liege; BélgicaFil: Gutkind, Gabriel Osvaldo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin